I find it easy to get overwhelmed by details, particularly in science where most research reveals around investigating one specific detail. There are so many facts and things to remember that I end up feeling hopeless and depressed.
So now I want to do something different. Instead start from the big idea and then go looking for the details that support and illuminate the idea. Reading scientific papers (which are usually not well-written) is like wading through a sea of details and hoping to re-construct the big idea that encompasses them. Very difficult and painful.